|
KMID : 0438219740110021173
|
|
Korea University Medical Journal
1974 Volume.11 No. 2 p.1173 ~ p.1181
|
|
|
An Experimental Study on Tissue Water Content of the Mouse Organs Following Thermal Burn
|
|
|
|
|
Abstract
|
|
|
One of the most p*rplexing subjects in pathologic physiology is water and electrolyte changes following burn. An experimental study was performed to clarify the changes of tissue water cotent of organs. 230 male S-M mice, weighing about 15-20gm were selected and divided into 4 groups of animal, group 1 as a control, group 2 with 10,/ burn, group 3 with 20% burn and group 4 with 30% burn. The burning technic was used an eletric iron with forming second degree in each animal. The tissue water contents were measured in the liver, spleen and kindey by the drying method after 4 hours, 1, 2, 3, 5, 7, and 10 days of experimental treatment. The results obtained are as follows:
1. Normal tissue water content of the liver, spleen and kidndy was 131.010.1, 97.35.3, and 92.6
7.5m1/kg, respectively.
2. In the liver, tissue water content decreasd, generally, to the half of its normal value, and recovery became more delayed relatively proportional to the areas of burn. However, increasing rate of tissue water content appeared evident during the recovery phase of 10% burn, regardless marked reduction in the early phase.
3. In spleen, as wide as area of burned surface tissue water content loss showed mild volume change;
in 20% and 30% burn groups there was more rapid increasing rate from early phase, but recovery
pattern became delayed in 10% group. During the recovery phase all groups showed marked accu-
mulation of water content above the level reaching almost 2 times of normal values at the 10th day.
4. In kidney with less wide burn surface, tissue water content loss was smaller but in 30% burn
group there showed increasing tendency from relatively early phase of burn and then water accu-
mulated almost 50% its normal value at the 10th day after burn.
5. Tissue water contents of each organ varied even with same area of burned surface, but recovery rate was assumed in inverse proportion to the amount of normal tissue water.
6. Changing patterns of tissue water contents in kidney and spleen appeared parallel during the recovery phase in contrast to persistent low level water con~eat in the liver, to result in wide range of increasing rates in such organs during recovery phase.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|